Article
Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients.
Cancer letters - 1 Oct 2021
Chen Yang, Li Yanyan, Qi Changsong, Zhang Cheng, Liu Dan, Deng Youping, Fu Yuanyuan, Khadka Vedbar S, Wang Daisy Dandan, Tan Shanyang, Liu Shujun, Peng Zhi, Gong Jifang, Lin Peter Ping, Zhang Xiaotian, Li Jian, Li Yilin, Shen Lin
Abstract excerpt
The mechanism by which heterogeneous-sized circulating tumor cells (CTCs) in gastric cancer (GC) patients are resistant to the targeted therapy and/or chemotherapy remains unclear. This study investigated prognostic value and genomic variations of size-heterogenous CTCs, in an attempt to unravel the molecular mechanisms underlying the therapeutic resistance, which is relevant to poor prognosis in GC. Aneuploid...
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