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Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents.

Scientific reports - 7 Jun 2021

Fuzo Carlos Alessandro, da Veiga Ued Fábio, Moco Sofia, Cominetti Ornella, Métairon Sylviane, Pruvost Solenn, Charpagne Aline, Carayol Jerome, Torrieri Raul, Silva Wilson Araujo, Descombes Patrick, Kaput Jim, Monteiro Jacqueline Pontes

Abstract excerpt

Polymorphisms in genes related to the metabolism of vitamin B12 haven't been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these genes and their SNPs with vitamin B12 levels; (c) determine a polygenic risk score (PRS) using significant variants. This...

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Identifiers

PMID: 34099811
DOI: 10.1038/s41598-021-91530-7
PMCID: PMC8184816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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