Article
A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil.
Genetics and molecular research : GMR - 31 Mar 2015
Coelho A V C, Moura R R, Cavalcanti C A J, Guimarães R L, Sandrin-Garcia P, Crovella S, Brandão L A C
Abstract excerpt
Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples' genetic background. The present study aimed to use a minimum...
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