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Article

MLH1 Exon 12 Gene Deletion Leading to Lynch Syndrome: A Case Report.

Oncology research and treatment - 1 Jan 2021

Cui Shiyun, Zhang Xiao, Zou Ruihan, Ye Fan, Wang Yutong, Sun Jing

Abstract excerpt

INTRODUCTION: Deleterious heterozygous mutation of the MLH1 gene is an important cause of Lynch syndrome (LS), an autosomal dominant cancer caused by functional defects in the DNA mismatch repair (MMR) complex. CASE REPORT: The proband was a 35-year-old patient with confirmed colorectal cancer (CRC). Immunohistochemical (IHC) staining revealed the absence of MLH1 and PMS2 expression in the colorectal tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34091457
DOI: 10.1159/000516659
PMCID: PMC8495764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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