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Article

[Molecular background of BRAF inhibitor induced resistance in BRAFV600E mutant melanoma cell lines].

Magyar onkologia - 3 Jun 2021

Szász István, Koroknai Viktória, Vízkeleti Laura, Balázs Margit

Abstract excerpt

Target-specific inhibition of the BRAFV600E mutant protein has been a major breakthrough in the treatment of metastatic cutaneous melanoma. However, the success of therapies is significantly overshadowed by the development of resistance. Understanding the molecular mechanisms associated with acquired resistance is an important step to increase the effectiveness of melanoma treatment. Our aim was to elucidate the...

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Share to Cell Line, Tumor
Share to Drug Resistance, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Kinase Inhibitors

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 34081762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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