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Article

[Mechanisms of resistance to anti-BRAF treatments].

Annales de dermatologie et de venereologie - 1 Nov 2014

Charles J, Martel C, de Fraipont F, Leccia M-T, Robert C, Busser B

Abstract excerpt

CONTEXT: In patients with melanoma positive for the BRAF V600 mutation, clinical response to specific BRAF inhibitors is usually rapid and striking, with significant benefits in terms of progression-free survival and overall survival. However, resistance to treatment almost invariably arises, typically within a median timeframe of 6 months. Indeed, very few patients exhibit long-lasting response to these targeted...

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Identifiers

PMID: 25442471
DOI: 10.1016/j.annder.2014.06.021

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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