Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the Neurokinin-1 Receptor as Targetable Stratification Factor for Drug Repurposing in Pancreatic Cancer

30 May 2021

Abstract excerpt

The SP/NK1R-complex plays an important role in tumor proliferation. Targeting of the neurokinin-1 receptor in previous studies with its antagonist aprepitant (AP) resulted in anti-tumoral effects in colorectal cancer and hepatoblastoma. However, there is still a lack of knowledge regarding its effects on pancreatic cancer. Therefore, we treated human pancreatic ductal adenocarcinoma (PDAC) cell lines (Capan-1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Neuroendocrine Tumor Research Advances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34070805
DOI: 10.3390/cancers13112703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the Neurokinin-1 Receptor as Targetable Stratification Factor for Drug Repurposing in Pancreatic CancerPMID 34070805Read ↗

Effective allogeneic natural killer cell therapy for pancreatic adenocarcinoma avails conserved activating receptors and evades HLA I-driven inhibitionSemantic proximity Read ↗

Targeting tachykinin receptors in neuroblastomaSemantic proximity Read ↗

A New Frontier in the Treatment of Cancer: NK-1 Receptor AntagonistsSemantic proximity Read ↗

New insight into the role of substance P/neurokinin‐1 receptor system in breast cancer progression and its crosstalk with microRNAsSemantic proximity Read ↗

NKD1 targeting PCM1 regulates the therapeutic effects of HHT on colorectal cancer cellsSemantic proximity Read ↗

The Role of Tachykinins in the Initiation and Progression of Gastrointestinal Cancers: A ReviewSemantic proximity Read ↗

The Combined Anti-Tumor Effects of 5-Fluorouracil and Neurokinin Receptor Inhibitor, Aprepitant, against Colorectal Cancer: In vitro and In vivo StudySemantic proximity Read ↗

MIA PaCa-2 and PANC-1 - pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors.Semantic proximity Read ↗

Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway.Semantic proximity Read ↗

Substance P and Neurokinin-1 receptor are overexpressed in adamantinomatous craniopharyngioma than in the pituitary glandSemantic proximity Read ↗

Investigating the Susceptibility of Treatment-Resistant Oesophageal Tumours to Natural Killer Cell-Mediated Responses.Semantic proximity Read ↗

Substance P Autocrine Signaling Contributes to Persistent HER2 Activation That Drives Malignant Progression and Drug Resistance in Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.