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Article

Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression?

International journal of molecular sciences - 16 May 2021

Trifonova Ekaterina A, Klimenko Alexandra I, Mustafin Zakhar S, Lashin Sergey A, Kochetov Alex V

Abstract excerpt

Autism spectrum disorder (ASD) is characterized by uncommon genetic heterogeneity and a high heritability concurrently. Most autoimmune disorders (AID), similarly to ASD, are characterized by impressive genetic heterogeneity and heritability. We conducted gene-set analyses and revealed that 584 out of 992 genes (59%) included in a new release of the SFARI Gene database and 439 out of 871 AID-associated genes...

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Identifiers

PMID: 34065644
DOI: 10.3390/ijms22105248
PMCID: PMC8156237

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