Article
Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa.
Nature communications - 26 May 2021
Benavente Ernest Diez, Manko Emilia, Phelan Jody, Campos Monica, Nolder Debbie, Fernandez Diana, Velez-Tobon Gabriel, Castaño Alberto Tobón, Dombrowski Jamille G, Marinho Claudio R F, Aguiar Anna Caroline C, Pereira Dhelio Batista, Sriprawat Kanlaya, Nosten Francois, Moon Robert, Sutherland Colin J, Campino Susana, Clark Taane G
Abstract excerpt
Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some...
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