Article
Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System.
The Journal of clinical endocrinology and metabolism - 18 Aug 2021
Puder Lia, Roth Sophie, Krabusch Philipp, Wiegand Susanna, Opitz Robert, Bald Martin, Flück Christa, Schulz Esther, Voss Egbert, Markó Lajos, Linz Peter, Berger Felix, Müller Dominik N, Kuehne Titus, Litt Michael J, Cone Roger D, Kühnen Peter, Kelm Marcus
Abstract excerpt
CONTEXT: Pro-opiomelanocortin (POMC) and the melanocortin-4 receptor (MC4R) play a pivotal role in the leptin-melanocortin pathway. Mutations in these genes lead to monogenic types of obesity due to severe hyperphagia. In addition to dietary-induced obesity, a cardiac phenotype without hypertrophy has been identified in MC4R knockout mice. OBJECTIVE: We aimed to characterize cardiac morphology and function as...
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