Article
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.
The Journal of allergy and clinical immunology - 1 Jan 2022
Groß Miriam, Speckmann Carsten, May Annette, Gajardo-Carrasco Tania, Wustrau Katharina, Maier Sarah Lena, Panning Marcus, Huzly Daniela, Agaimy Abbas, Bryceson Yenan T, Choo Sharon, Chow C W, Dückers Gregor, Fasth Anders, Fraitag Sylvie, Gräwe Katja, Haxelmans Sabine, Holzinger Dirk, Hudowenz Ole, Hübschen Judith M, Khurana Claudia, Kienle Korbinian, Klifa Roman, Korn Klaus, Kutzner Heinz, Lämmermann Tim, Ledig Svea, Lipsker Dan, Meeths Marie, Naumann-Bartsch Nora, Rascon Jelena, Schänzer Anne, Seidl Maximilian, Tesi Bianca, Vauloup-Fellous Christelle, Vollmer-Kary Beate, Warnatz Klaus, Wehr Claudia, Neven Bénédicte, Vargas Pablo, Sepulveda Fernando E, Lehmberg Kai, Schmitt-Graeff Annette, Ehl Stephan
Abstract excerpt
BACKGROUND: Rubella virus-induced granulomas have been described in patients with various inborn errors of immunity. Most defects impair T-cell immunity, suggesting a critical role of T cells in rubella elimination. However, the molecular mechanism of virus control remains elusive. OBJECTIVE: This study sought to understand the defective effector mechanism allowing rubella vaccine virus persistence in granulomas....
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