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Article

Distinct Clinical Physiologic Phenotypes of Patients With Laryngeal Symptoms Referred for Reflux Evaluation.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Apr 2022

Yadlapati Rena, Kaizer Alexander M, Sikavi Daniel R, Greytak Madeline, Cai Jennifer X, Carroll Thomas L, Gupta Samir, Wani Sachin, Menard-Katcher Paul, Wu Tsung-Chin, Weissbrod Philip, Vahabzadeh-Hagh Andrew M, Pandolfino John E, Chan Walter W

Abstract excerpt

BACKGROUND & AIMS: Heterogeneous presentations and disease mechanisms among patients with laryngeal symptoms account for misdiagnosis of laryngopharyngeal reflux (LPR), variations in testing, and suboptimal outcomes. We aimed to derive phenotypes of patients with laryngeal symptoms based on clinical and physiologic data and to compare characteristics across phenotypes. METHODS: A total of 302 adult patients with...

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PMID: 34022451
DOI: 10.1016/j.cgh.2021.05.025
PMCID: PMC8715518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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