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Article

Benchmarking association analyses of continuous exposures with RNA-seq in observational studies.

Briefings in bioinformatics - 5 Nov 2021

Sofer Tamar, Kurniansyah Nuzulul, Aguet François, Ardlie Kristin, Durda Peter, Nickerson Deborah A, Smith Joshua D, Liu Yongmei, Gharib Sina A, Redline Susan, Rich Stephen S, Rotter Jerome I, Taylor Kent D

Abstract excerpt

Large datasets of hundreds to thousands of individuals measuring RNA-seq in observational studies are becoming available. Many popular software packages for analysis of RNA-seq data were constructed to study differences in expression signatures in an experimental design with well-defined conditions (exposures). In contrast, observational studies may have varying levels of confounding transcript-exposure...

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Identifiers

PMID: 34015820
DOI: 10.1093/bib/bbab194
PMCID: PMC8574950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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