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Article

Decreased ATM Function Causes Delayed DNA Repair and Apoptosis in Common Variable Immunodeficiency Disorders.

Journal of clinical immunology - 1 Aug 2021

Hargreaves Chantal E, Salatino Silvia, Sasson Sarah C, Charlesworth James E G, Bateman Elizabeth, Patel Arzoo M, Anzilotti Consuelo, Broxholme John, Knight Julian C, Patel Smita Y

Abstract excerpt

PURPOSE: Common variable immunodeficiency disorders (CVID) is characterized by low/absent serum immunoglobulins and susceptibility to bacterial infection. Patients can develop an infections-only phenotype or a complex disease course with inflammatory, autoimmune, and/or malignant complications. We hypothesized that deficient DNA repair mechanisms may be responsible for the antibody deficiency and susceptibility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34009545
DOI: 10.1007/s10875-021-01050-2
PMCID: PMC8310859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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