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Article

JunB is a key regulator of multiple myeloma bone marrow angiogenesis

18 May 2021

Abstract excerpt

Bone marrow (BM) angiogenesis significantly influences disease progression in multiple myeloma (MM) patients and correlates with adverse prognosis. The present study shows a statistically significant correlation of the AP-1 family member JunB with VEGF, VEGFB, and IGF1 expression levels in MM. In contrast to the angiogenic master regulator Hif-1α, JunB protein levels were independent of hypoxia. Results in...

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PMID: 34007044
DOI: 10.1038/s41375-021-01271-9

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