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Article

Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma.

Blood - 7 Jan 2010

Chen Lijuan, Wang Siqing, Zhou Yiming, Wu Xiaosong, Entin Igor, Epstein Joshua, Yaccoby Shmuel, Xiong Wei, Barlogie Bart, Shaughnessy John D, Zhan Fenghuang

Abstract excerpt

Tumor-bone marrow microenvironment interactions in multiple myeloma (MM) are documented to play crucial roles in plasma-cell growth/survival. In vitro coculture of MM cells with osteoclasts supported cell survival and significantly down-regulated JUN expression. JUN expression in myeloma cells from late-stage and high-risk MM was significantly lower than in plasma cells from healthy donors, monoclonal gammopathy...

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Identifiers

PMID: 19837979
DOI: 10.1182/blood-2009-03-210526
PMCID: PMC2803692

Genes

JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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