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Article

X-chromosome variants are associated with aldosterone producing adenomas.

Scientific reports - 18 May 2021

Dutta Ravi Kumar, Larsson Malin, Arnesen Thomas, Heie Anette, Walz Martin, Alesina Piero, Gimm Oliver, Söderkvist Peter

Abstract excerpt

Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism (PA) and are characterized by constitutively producing aldosterone, which leads to hypertension. Several mutations have been identified in ion channels or ion channel-associated genes that result in APAs. To date, no studies have used a genome-wide association study (GWAS) approach to search for predisposing loci for APAs. Thus, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34006971
DOI: 10.1038/s41598-021-89986-8
PMCID: PMC8131628

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