Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells.

doi:10.1002/hep.31888

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Article

Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells.

Hepatology (Baltimore, Md.) - 1 Oct 2021

Gentilini Alessandra, Lori Giulia, Caligiuri Alessandra, Raggi Chiara, Di Maira Giovanni, Pastore Mirella, Piombanti Benedetta, Lottini Tiziano, Arcangeli Annarosa, Madiai Stefania, Navari Nadia, Banales Jesus M, Di Matteo Sabina, Alvaro Domenico, Duwe Lea, Andersen Jesper B, Tubita Alessandro, Tusa Ignazia, Di Tommaso Luca, Campani Claudia, Rovida Elisabetta, Marra Fabio

Abstract excerpt

BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been explored. The aim of this study was to investigate the role of ERK5 in the biology of CCA. APPROACH AND RESULTS: ERK5 expression was detected in two established...

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PMID: 33959996
DOI: 10.1002/hep.31888
PMCID: PMC8518067

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