Article
Patient personalized translational tools in cystic fibrosis to transform data from bench to bed-side and back.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2021
Arora Kavisha, Yang Fanmuyi, Brewington John, McPhail Gary, Cortez Alexander R, Sundaram Nambirajan, Ramananda Yashaswini, Ogden Herbert, Helmrath Michael, Clancy John P, Naren Anjaparavanda P
Abstract excerpt
Cystic fibrosis is a deadly multiorgan disorder caused by loss of function mutations in the gene that encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) chloride/bicarbonate ion channel. More than 1,700 CFTR genetic variants exist that can cause CF, and majority of these are extremely rare. Because of genetic and environmental influences, CF patients exhibit large phenotypic variation....
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