Article
Functional identification of a rare vascular endothelial growth factor a (VEGFA) variant associating with the nonsyndromic cleft lip with/without cleft palate.
Bioengineered - 1 Dec 2021
Sun Bohui, Liu Yangjia, Huang Wenbin, Zhang Qian, Lin Jiuxiang, Li Weiran, Zhang Jieni, Chen Feng
Abstract excerpt
Vascular endothelial growth factor A (VEGFA) is a crucial growth factor, which participates in multiple processes of human growth and development, such as angiogenesis and osteogenesis and is also necessary for development of palate. The purpose of this study was to investigate the effect of a rare VEGFA mutation (NM_001025366.2 773 T > C p.Val258Ala) on the cell functions and osteogenesis. Here, we found that...
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