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Article

Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations.

Blood advances - 11 May 2021

Heuser Michael, Heida Bennet, Büttner Konstantin, Wienecke Clara Philine, Teich Katrin, Funke Carolin, Brandes Maximilian, Klement Piroska, Liebich Alessandro, Wichmann Martin, Neziri Blerina, Chaturvedi Anuhar, Kloos Arnold, Mintzas Konstantinos, Gaidzik Verena I, Paschka Peter, Bullinger Lars, Fiedler Walter, Heim Albert, Puppe Wolfram, Krauter Jürgen, Döhner Konstanze, Döhner Hartmut, Ganser Arnold, Stadler Michael, Hambach Lothar, Gabdoulline Razif, Thol Felicitas

Abstract excerpt

Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML) is widely applicable and prognostic prior to allogeneic hematopoietic cell transplantation (alloHCT). We evaluated the prognostic role of clonal hematopoiesis-associated DNMT3A, TET2, and ASXL1 (DTA) and non-DTA mutations for MRD monitoring post-alloHCT to refine MRD marker selection....

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Identifiers

PMID: 33929500
DOI: 10.1182/bloodadvances.2021004367
PMCID: PMC8114555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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