Article
Pre-Senescence Induction in Hepatoma Cells Favors Hepatitis C Virus Replication and Can Be Used in Exploring Antiviral Potential of Histone Deacetylase Inhibitors.
International journal of molecular sciences - 27 Apr 2021
Malikova Alsu Z, Shcherbakova Anastasia S, Konduktorov Konstantin A, Zemskaya Anastasia S, Dalina Alexandra A, Popenko Vladimir I, Leonova Olga G, Morozov Alexei V, Kurochkin Nikolay N, Smirnova Olga A, Kochetkov Sergey N, Kozlov Maxim V
Abstract excerpt
Recent evidence suggests that fibrotic liver injury in patients with chronic hepatitis C correlates with cellular senescence in damaged liver tissue. However, it is still unclear how senescence can affect replication of the hepatitis C virus (HCV). In this work, we report that an inhibitor of cyclin-dependent kinases 4/6, palbociclib, not only induced in hepatoma cells a pre-senescent cellular phenotype,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.