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Article

Promotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy.

Cell communication and signaling : CCS - 21 Sept 2022

Wei Shanshan, Hu Wenwei, Feng Jun, Geng Yiting

Abstract excerpt

Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) patients. However, the generation of primary and secondary resistance to anti-EGFR mAbs has become an important factor restricting its efficacy. Recent studies have revealed that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs),...

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Identifiers

PMID: 36131281
DOI: 10.1186/s12964-022-00960-x
PMCID: PMC9490904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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