Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

22 Apr 2021

Abstract excerpt

Silencing of tumor suppressor genes (TSGs) through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is considered a main mechanism of tumorigenesis. The abnormal DNA methylation profiles are transmitted from the cancer mother cell to the daughter cells through the involvement of a macromolecular complex in which the ubiquitin-like containing plant homeodomain (PHD), and an interesting new gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Signaling Pathway Studies
Share to Histone Deacetylase Inhibitors Research
Share to Natural Compounds in Disease Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33922029
DOI: 10.3390/genes12050622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein ComplexPMID 33922029Read ↗

Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeuticsSemantic proximity Read ↗

Epigenetic Impact of Curcumin and Thymoquinone on Cancer TherapeuticsSemantic proximity Read ↗

UHRF1 Is a Novel Druggable Epigenetic Target in Malignant Pleural MesotheliomaSemantic proximity Read ↗

Small-Molecule Inhibitors Targeting FEN1 for Cancer TherapySemantic proximity Read ↗

Targeting microRNAs with thymoquinone: a new approach for cancer therapySemantic proximity Read ↗

Diosgenin Inhibits Prostate Cancer Progression by Inducing UHRF1 Protein DegradationSemantic proximity Read ↗

UHRF1 depletion sensitizes retinoblastoma cells to chemotherapeutic drugs via downregulation of XRCC4Semantic proximity Read ↗

Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastomaSemantic proximity Read ↗

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling PathwaySemantic proximity Read ↗

Ellagic acid: a potential inhibitor of enhancer of zeste homolog-2 and protein arginine methyltransferase-5Semantic proximity Read ↗

Ameliorative Inhibition of SIRT6 by Imidazole Derivative Triggers Oxidative Stress-Mediated Apoptosis Associated with Nrf2/Keap1 Signaling in NSCLC Cell LinesSemantic proximity Read ↗

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.