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Modeling Neoplastic Growth in Renal Cell Carcinoma and Polycystic Kidney Disease

10 Apr 2021

Abstract excerpt

Renal cell carcinoma (RCC) and autosomal dominant polycystic kidney disease (ADPKD) share several characteristics, including neoplastic cell growth, kidney cysts, and limited therapeutics. As well, both exhibit impaired vasculature and compensatory VEGF activation of angiogenesis. The PI3K/AKT/mTOR and Ras/Raf/ERK pathways play important roles in regulating cystic and tumor cell proliferation and growth. Both RCC...

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PMID: 33920158
DOI: 10.3390/ijms22083918

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