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Can molecular mimicry explain the cytokine storm of SARS‐CoV‐2?: An in silico approach

29 Apr 2021

Abstract excerpt

PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus...

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PMID: 33913542
DOI: 10.1002/jmv.27040

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