Article
Genome-Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence.
The Journal of urology - 1 Sept 2021
Cartwright Rufus, Franklin Larissa, Tikkinen Kari A O, Kalliala Ilkka, Miotla Pawel, Rechberger Tomasz, Offiah Ifeoma, McMahon Steve, O'Reilly Barry, Lince Sabrina, Kluivers Kirsten, Post Wilke M, Poelmans Geert, Palmer Melody R, Wessells Hunter, Wong Andrew, Kuh Diana, Kivimaki Mika, Kumari Meena, Mangino Massimo, Spector Tim, Guggenheim Jeremy A, Lehne Benjamin, De Silva N Maneka G, Evans David M, Lawlor Debbie, Karhunen Ville, Männikkö Minna, Marczak Malgorzata, Bennett Phillip R, Khullar Vik, Järvelin Marjo-Riitta, Walley Andrew
Abstract excerpt
PURPOSE: Genome-wide association studies have not identified replicable genetic risk loci for stress or urgency urinary incontinence. MATERIALS AND METHODS: We carried out a discovery stage, case control, genome-wide association study in 3 independent discovery cohorts of European women (8,979) for stress incontinence, urgency incontinence, and any incontinence phenotypes. We conducted replication in 6 additional...
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