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Article

Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height.

The Journal of clinical endocrinology and metabolism - 16 Jun 2021

Shi Mingjian, Manouchehri Ali M, Shaffer Christian M, Vaitinadin Nataraja Sarma, Hellwege Jacklyn N, Salem Joe-Elie, Davis Lea K, Simmons Jill H, Roden Dan M, Shoemaker M Benjamin, Ferguson Jane F, Mosley Jonathan D

Abstract excerpt

CONTEXT: A genetic predisposition to lower thyrotropin (TSH) levels is associated with increased atrial fibrillation (AF) risk through undefined mechanisms. OBJECTIVE: Defining the genetic mediating mechanisms could lead to improved targeted therapies to mitigate AF risk. METHODS: We used 2-sample mendelian randomization (MR) to test associations between TSH-associated single-nucleotide variations and 16...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33895829
DOI: 10.1210/clinem/dgab272
PMCID: PMC8208678

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