Article
Task matters - challenging the motor system allows distinguishing unaffected Parkin mutation carriers from mutation-free controls.
Parkinsonism & related disorders - 1 May 2021
Prasuhn Jannik, Borsche Max, Hicks Andrew A, Gögele Martin, Egger Clemens, Kritzinger Cleo, Pichler Irene, Castelo-Rueda Maria Paulina, Langlott Lynn, Kasten Meike, Mascalzoni Deborah, Klein Christine, Pramstaller Peter P, Brüggemann Norbert
Abstract excerpt
BACKGROUND: Heterozygous carriers of Parkin mutations are suggested to be at risk of developing Parkinson's disease, while biallelic variants are associated with typical autosomal recessive early-onset PD. Investigating unaffected heterozygous mutation carriers holds the potential of a deeper understanding of monogenic PD and has implications for PD in general, in particular regarding the prodromal phase....
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