Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Puerarin blocks the aging phenotype in human dermal fibroblasts.

PloS one - 1 Jan 2021

Kamiya Yuki, Odama Mao, Mizuguti Aki, Murakami Shigeru, Ito Takashi

Abstract excerpt

Dermal fibroblast aging contributes to aging-associated functional defects in the skin since dermal fibroblasts maintain skin homeostasis by interacting with the epidermis and extracellular matrix. Here, we found that puerarin, an isoflavone present in Pueraria lobata (Kudzu), can prevent the development of the aging-phenotype in human dermal fibroblasts. Normal human dermal fibroblasts (NHDFs) were subcultivated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Calcium-Binding Proteins
Share to Calponins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Dermis

Share to Isoflavones

Share to Microfilament Proteins

Share to Myofibroblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 33886592
DOI: 10.1371/journal.pone.0249367
PMCID: PMC8061915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Puerarin blocks the aging phenotype in human dermal fibroblasts.PMID 33886592Read ↗

Puerarin blocks aging phenotype in cultured human dermal fibroblastsSemantic proximity Read ↗

Novel Senolytic Ingredient, Camellia sinensis Root Extract, Ameliorates Skin Aging-Associated PhenotypesSemantic proximity Read ↗

Cistanche deserticola Polysaccharide Reduces Inflammation and Aging Phenotypes in the Dermal Fibroblasts through the Activation of the NRF2/HO-1 Pathway.Semantic proximity Read ↗

Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging.Semantic proximity Read ↗

Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo.Semantic proximity Read ↗

Soy Isoflavone Glycitin (4'-Hydroxy-6-Methoxyisoflavone-7-D-Glucoside) Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF-β SignalingSemantic proximity Read ↗

Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expressionSemantic proximity Read ↗

Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo studySemantic proximity Read ↗

Astragaloside IV alleviates skin fibrosis by modulating fibroblast phenotype in keloids.Semantic proximity Read ↗

Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.