Clinical significance of immunohistochemistry to detect BRAF V600E mutant protein in thyroid tissues.

doi:10.1097/MD.0000000000025566

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Clinical significance of immunohistochemistry to detect BRAF V600E mutant protein in thyroid tissues.

Medicine - 23 Apr 2021

Zhang Yini, Liu Lidan, Liu Ye, Cao Nan, Wang Lifen, Xing Chengjuan

Abstract excerpt

ABSTRACT: This study investigated the feasibility of using immunohistochemistry (IHC) instead of PCR to detect BRAF V600E mutant protein in papillary thyroid carcinoma (PTC), and to determine the value of using preoperative BRAF V600E mutant protein by IHC to assist in the diagnosis of thyroid nodule patients with Hashimoto's thyroiditis (HT).The expression of BRAFV600E mutant protein was measured in 23 cases of...

Topics

Adult
Feasibility Studies
Female
Hashimoto Disease
Humans
Immunohistochemistry
Male
Middle Aged
Mutant Proteins
Mutation
Paraffin Embedding
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Preoperative Period

Proto-Oncogene Proteins B-raf

Sensitivity and Specificity

Staining and Labeling

Thyroid Cancer, Papillary

Source

Open in PubMed Open full text

Identifiers

PMID: 33879712
DOI: 10.1097/MD.0000000000025566
PMCID: PMC8078443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33879712-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical significance of immunohistochemistry to detect BRAF V600E mutant protein in thyroid tissues.PMID 33879712Read ↗

The BRAF V600E Mutation and Clinicopathological Changes Among Patients With Hashimoto Thyroiditis, Papillary Thyroid Carcinoma With Hashimoto Thyroiditis, and Nodular Goiter.Semantic proximity Read ↗

Diagnostic value of FNAC combined with BRAFV600E mutation detection in Hashimoto's thyroiditis complicated with papillary thyroid carcinoma.Semantic proximity Read ↗

Potential relationship between Hashimoto's thyroiditis and BRAF(V600E) mutation status in papillary thyroid cancer.Semantic proximity Read ↗

Utility of BRAF immunohistochemistry for the detection of BRAF mutations in papillary thyroid carcinoma. Analysis of detailed histological subtypes.Semantic proximity Read ↗

Various Roles of Hashimoto's Thyroiditis and Thyroid Function in Papillary Thyroid Micro- and Macro-carcinomaSemantic proximity Read ↗

Correlation Between the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated with Hashimoto's Thyroiditis, BRAF V600E Gene Mutation, and RET Gene Rearrangement.Semantic proximity Read ↗

mRNA BRAF expression helps to identify papillary thyroid carcinomas in thyroid nodules independently of the presence of BRAFV600E mutation.Semantic proximity Read ↗

Clinical utility of immunohistochemistry for the detection of the BRAF v600e mutation in papillary thyroid carcinoma.Semantic proximity Read ↗

Association between BRAF V600E Mutation and Ultrasound Features in Papillary Thyroid Carcinoma Patients with and without Hashimoto's Thyroiditis.Semantic proximity Read ↗

Mutations of the <i>BRAF</i> gene in papillary thyroid carcinoma and in Hashimoto's thyroiditisSemantic proximity Read ↗

Application of Immunohistochemistry in Papillary Thyroid Carcinoma.Semantic proximity Read ↗

Effect and Interactions of BRAF on Lymph Node Metastasis in Papillary Thyroid Carcinoma With Hashimoto Thyroiditis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.