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Article

Local adaptation of Mycobacterium tuberculosis on the Tibetan Plateau.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2021

Liu Qingyun, Liu Haican, Shi Li, Gan Mingyu, Zhao Xiuqin, Lyu Liang-Dong, Takiff Howard E, Wan Kanglin, Gao Qian

Abstract excerpt

During its global dispersal, Mycobacterium tuberculosis (Mtb) has encountered varied geographic environments and host populations. Although local adaptation seems to be a plausible model for describing long-term host-pathogen interactions, genetic evidence for this model is lacking. Here, we analyzed 576 whole-genome sequences of Mtb strains sampled from different regions of high-altitude Tibet. Our results show...

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Identifiers

PMID: 33879609
DOI: 10.1073/pnas.2017831118
PMCID: PMC8092575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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