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Article

Poly (ADP-ribose) polymerase inhibitors in solid tumours: Systematic review and meta-analysis.

European journal of cancer (Oxford, England : 1990) - 1 May 2021

Schettini Francesco, Giudici Fabiola, Bernocchi Ottavia, Sirico Marianna, Corona Silvia P, Giuliano Mario, Locci Mariavittoria, Paris Ida, Scambia Giovanni, De Placido Sabino, Rescigno Pasquale, Prat Aleix, Curigliano Giuseppe, Generali Daniele

Abstract excerpt

BACKGROUND: Poly (ADP-ribose) polymerase-inhibitors (PARPis) showed antitumour activity in BRCA1/2-mutated cancers, with more heterogeneous outcomes in tumours harbouring mutations that impair other genes involved in the DNA homologous recombination repair (HRR) or wild-type (wt). METHODS: We conducted a systematic review and meta-analysis to better assess the role of PARPis in the treatment of metastatic solid...

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Identifiers

PMID: 33862496
DOI: 10.1016/j.ejca.2021.02.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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