Article
Multilevel prioritization of gene regulators associated with consensus molecular subtypes of colorectal cancer.
Briefings in bioinformatics - 2 Sept 2021
Song Kai, Cai Hao, Zheng Hailong, Yang Jing, Jin Liangliang, Xiao Huiting, Zhang Jiashuai, Zhao Zhangxiang, Li Xin, Zhao Wenyuan, Li Xia
Abstract excerpt
Consensus molecular subtypes (CMSs) are emerging as critical factor for prognosis and treatment of colorectal cancer. Gene regulators, including chromatin regulator, RNA-binding protein and transcriptional factor, are critical modulators of cancer hallmark, yet little is known regarding the underlying functional mechanism in CMSs. Herein, we identified a core set of 235 functional gene regulators (FGRs) by...
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