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Article

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.

Translational psychiatry - 14 Jun 2016

Short A K, Fennell K A, Perreau V M, Fox A, O'Bryan M K, Kim J H, Bredy T W, Pang T Y, Hannan A J

Abstract excerpt

Recent studies have suggested that physiological and behavioral traits may be transgenerationally inherited through the paternal lineage, possibly via non-genomic signals derived from the sperm. To investigate how paternal stress might influence offspring behavioral phenotypes, a model of hypothalamic-pituitary-adrenal (HPA) axis dysregulation was used. Male breeders were administered water supplemented with...

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Identifiers

PMID: 27300263
DOI: 10.1038/tp.2016.109
PMCID: PMC4931607

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CORT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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