Article
A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment.
Nature communications - 9 Apr 2021
Kinoshita-Daitoku Ryo, Kiga Kotaro, Miyakoshi Masatoshi, Otsubo Ryota, Ogura Yoshitoshi, Sanada Takahito, Bo Zhu, Phuoc Tuan Vo, Okano Tokuju, Iida Tamako, Yokomori Rui, Kuroda Eisuke, Hirukawa Sayaka, Tanaka Mototsugu, Sood Arpana, Subsomwong Phawinee, Ashida Hiroshi, Binh Tran Thanh, Nguyen Lam Tung, Van Khien Vu, Ho Dang Quy Dung, Nakai Kenta, Suzuki Toshihiko, Yamaoka Yoshio, Hayashi Tetsuya, Mimuro Hitomi
Abstract excerpt
Long-term infection of the stomach with Helicobacter pylori can cause gastric cancer. However, the mechanisms by which the bacteria adapt to the stomach environment are poorly understood. Here, we show that a small non-coding RNA of H. pylori (HPnc4160, also known as IsoB or NikS) regulates the pathogen's adaptation to the host environment as well as bacterial oncoprotein production. In a rodent model of H....
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