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Article

Multi-omics analysis of tumor mutation burden combined with immune infiltrates in melanoma.

Clinica chimica acta; international journal of clinical chemistry - 1 Dec 2020

Jiang Feng, Wu Chuyan, Wang Ming, Wei Ke, Zhou Guoping, Wang Jimei

Abstract excerpt

BACKGROUND: In multiple malignancies, whether tumor mutation burden (TMB) correlated with increased survival or promotion of immunotherapy remained a debate. Our aim was to analyze the prognosis of TMB and the possible connection with immune infiltration of the skin cutaneous melanoma (SKCM). METHODS: We gathered somatic mutation data from the 472 SKCM patients using the Cancer Genome Atlas (TCGA) database and...

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PMID: 33164879
DOI: 10.1016/j.cca.2020.10.030

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