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Article

Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model.

The pharmacogenomics journal - 1 Aug 2021

Yuliwulandari Rika, Shin Jae Gook, Kristin Erna, Suyatna Fransiscus D, Prahasto Iwan Dwi, Prayuni Kinasih, Mahasirimongkol Surakameth, Cavallari Larisa H, Mitropoulou Christina, Patrinos George P, Hao Jing, Williams Marc S, Snyder Susan R

Abstract excerpt

Carbamazepine (CBZ)-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling clinicians to prescribe alternative therapy for positive patients. Similar to other Southeastern Asian countries, HLA-B*15:02 is highly prevalent in Indonesia. Therefore, we...

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Identifiers

PMID: 33824430
DOI: 10.1038/s41397-021-00225-9
PMCID: PMC9059703

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