Article
The RD2 Pathogenicity Island Modifies the Disease Potential of the Group A Streptococcus.
Infection and immunity - 15 Jul 2021
Roshika Roshika, Jain Ira, Medicielo Josette, Wächter Jasmin, Danger Jessica L, Sumby Paul
Abstract excerpt
Serotype M28 isolates of the group A Streptococcus (GAS; Streptococcus pyogenes) are nonrandomly associated with cases of puerperal sepsis, a potentially life-threatening infection that can occur in women following childbirth. Previously, we discovered that the 36.3-kb RD2 pathogenicity island, which is present in serotype M28 isolates but lacking from most other isolates, promotes the ability of M28 GAS to...
Topics
- Cell Line
- DNA Transposable Elements
- Gain of Function Mutation
- Genomic Islands
- Humans
- Phenotype
- Sepsis
- Serogroup
- Streptococcal Infections
- Streptococcus pyogenes