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Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene.

Journal of genetics and genomics = Yi chuan xue bao - 20 Jan 2021

Hartley Paul D, Tillett Richard L, AuCoin David P, Sevinsky Joel R, Xu Yanji, Gorzalski Andrew, Pandori Mark, Buttery Erin, Hansen Holly, Picker Michael A, Rossetto Cyprian C, Verma Subhash C

Abstract excerpt

Patients with signs of COVID-19 were tested through diagnostic RT-PCR for SARS-CoV-2 using RNA extracted from the nasopharyngeal/nasal swabs. To determine the variants of SARS-CoV-2 circulating in the state of Nevada, specimens from 200 COVID-19 patients were sequenced through our robust sequencing platform, which enabled sequencing of SARS-CoV-2 from specimens with even very low viral loads, without the need of...

Topics

COVID-19
Coronavirus RNA-Dependent RNA Polymerase
Genome, Viral
Humans
Models, Molecular
Mutation
Nasopharynx
Nevada
Phylogeny
Prevalence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

SARS-CoV-2

Spike Glycoprotein, Coronavirus

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Open in PubMed Open full text

Identifiers

PMID: 33820739
DOI: 10.1016/j.jgg.2021.01.004
PMCID: PMC7891100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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