Interleukin-8 genetic diversity, haplotype structure and production differ in two ethnically distinct South African populations.

doi:10.1016/j.cyto.2021.155489

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Article

Interleukin-8 genetic diversity, haplotype structure and production differ in two ethnically distinct South African populations.

Cytokine - 1 Jul 2021

Paximadis Maria, Picton Anabela C P, Sengupta Dhriti, Ramsay Michele, Puren Adrian, Tiemessen Caroline T

Abstract excerpt

A single nucleotide polymorphism (SNP), 251 bases upstream from the IL-8 transcription start (-251A>T, rs4073), has been extensively investigated in cancers and inflammatory and infectious diseases in predominantly European and Asian populations. We sequenced the IL-8 gene of 109 black and 32 white South African (SA) individuals and conducted detailed characterization of gene variation and haplotype structure....

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PMID: 33814271
DOI: 10.1016/j.cyto.2021.155489

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