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Article

Meta-Analysis of Noncompartmental Pharmacokinetic Parameters of Ertugliflozin to Evaluate Dose Proportionality and UGT1A9 Polymorphism Effect on Exposure.

Journal of clinical pharmacology - 1 Sept 2021

Marshall Jean-Claude, Liang Yali, Sahasrabudhe Vaishali, Tensfeldt Thomas, Fediuk Daryl J, Zhou Susan, Krishna Rajesh, Dawra Vikas Kumar, Wood Linda S, Sweeney Kevin

Abstract excerpt

Ertugliflozin, a sodium-glucose cotransporter 2 inhibitor, is primarily metabolized via glucuronidation by the uridine 5'-diphospho-glucuronosyltransferase (UGT) isoform UGT1A9. This noncompartmental meta-analysis of ertugliflozin pharmacokinetics evaluated the relationship between ertugliflozin exposure and dose, and the effect of UGT1A9 genotype on ertugliflozin exposure. Pharmacokinetic data from 25 phase 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33813736
DOI: 10.1002/jcph.1866
PMCID: PMC8453771

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