Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.

doi:10.1093/jac/dkaa444

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Article

Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.

The Journal of antimicrobial chemotherapy - 19 Jan 2021

Salpini Romina, Alkhatib Mohammad, Costa Giosuè, Piermatteo Lorenzo, Ambrosio Francesca Alessandra, Di Maio Velia Chiara, Scutari Rossana, Duca Leonardo, Berno Giulia, Fabeni Lavinia, Alcaro Stefano, Ceccherini-Silberstein Francesca, Artese Anna, Svicher Valentina

Abstract excerpt

OBJECTIVES: To define key genetic elements, single or in clusters, underlying SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) evolutionary diversification across continents, and their impact on drug-binding affinity and viral antigenicity. METHODS: A total of 12 150 SARS-CoV-2 sequences (publicly available) from 69 countries were analysed. Mutational clusters were assessed by hierarchical clustering....

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Identifiers

PMID: 33254234
DOI: 10.1093/jac/dkaa444
PMCID: PMC7799093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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