The Decisive Case-Control Study Elaborates the Null Association between ESR1 XbaI and Osteoarthritis in Asians: A Case-Control Study and Meta-Analysis.

doi:10.3390/genes12030404

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The Decisive Case-Control Study Elaborates the Null Association between ESR1 XbaI and Osteoarthritis in Asians: A Case-Control Study and Meta-Analysis.

Genes - 12 Mar 2021

Huang Yu-Hao, Fang Wen-Hui, Tsai Dung-Jang, Chen Yu-Hsuan, Wang Yu-Chiao, Su Wen, Kao Chung-Cheng, Yi Kevin, Wang Chih-Chien, Su Sui-Lung

Abstract excerpt

(1) Background: The prevalence of knee osteoarthritis (OA) in women is significantly higher than in men. The estrogen receptor α (ERα) has been considered to play a key role due to a large gender difference in its expression. ERα is encoded by the gene estrogen receptor 1 (ESR1), which is widely studied to explore the gender difference in knee OA. Several polymorphisms in ESR1 [PvuII (rs2234693) and BtgI...

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PMID: 33808990
DOI: 10.3390/genes12030404
PMCID: PMC7999595

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