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Article

De novo mutation of cancer-related genes associates with particular neurodevelopmental disorders.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2020

Li Bin, Li Kuokuo, Tian Di, Zhou Qiao, Xie Yali, Fang Zhenghuan, Wang Xiaomeng, Luo Tengfei, Wang Zheng, Zhang Yi, Wang Yijing, Chen Qian, Meng Qingtuan, Zhao Guihu, Li Jinchen

Abstract excerpt

Epidemiological studies have shown an increased prevalence of cancer in some patients with neurodevelopmental disorder (NDD); however, the genetic mechanisms regarding how cancer-related genes (CRGs) contribute to NDD remain unclear. We performed bioinformatic analyses on 219 CRGs from OMIM and de novo mutations (DNMs) from 16,498 patients with different NDDs and 3391 controls. Our results showed that autism...

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PMID: 33047154
DOI: 10.1007/s00109-020-01991-y

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