Article
Genetic Predisposition to Myelodysplastic Syndromes: A Challenge for Adult Hematologists.
International journal of molecular sciences - 3 Mar 2021
Crisà Elena, Boggione Paola, Nicolosi Maura, Mahmoud Abdurraouf Mokhtar, Al Essa Wael, Awikeh Bassel, Aspesi Anna, Andorno Annalisa, Boldorini Renzo, Dianzani Irma, Gaidano Gianluca, Patriarca Andrea
Abstract excerpt
Myelodysplastic syndromes (MDS) arising in the context of inherited bone marrow failure syndromes (IBMFS) differ in terms of prognosis and treatment strategy compared to MDS occurring in the adult population without an inherited genetic predisposition. The main molecular pathways affected in IBMFS involve telomere maintenance, DNA repair, biogenesis of ribosomes, control of proliferation and others. The increased...
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