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Article

Causal Effects of Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism on Kidney Function: A Mendelian Randomization Study.

Journal of the American Society of Nephrology : JASN - 1 Jun 2021

Park Sehoon, Lee Soojin, Kim Yaerim, Lee Yeonhee, Kang Min Woo, Kim Kwangsoo, Kim Yong Chul, Han Seung Seok, Lee Hajeong, Lee Jung Pyo, Joo Kwon Wook, Lim Chun Soo, Kim Yon Su, Kim Dong Ki

Abstract excerpt

BACKGROUND: Further investigation of the causal effects of psychologic wellbeing on kidney function is warranted. METHODS: In this Mendelian randomization (MR) study, genetic instruments for positive affect, life satisfaction, depressive symptoms, and neuroticism were introduced from a previous genome-wide association study meta-analysis of European individuals. Summary-level MR was performed using the CKDGen...

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Identifiers

PMID: 33785582
DOI: 10.1681/ASN.2020071086
PMCID: PMC8259638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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