Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.

doi:10.1097/HJH.0000000000002846

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Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.

Journal of hypertension - 1 Sept 2021

Wang Yang, Jia Hao, Gao Wei-Hua, Zou Ting, Yao Shi, Du Ming-Fei, Zhang Xiao-Yu, Chu Chao, Liao Yue-Yuan, Chen Chen, Wang Dan, Ma Qiong, Hu Jia-Wen, Wang Ke-Ke, Yan Yu, Sun Yue, Hu Gui-Lin, Niu Ze-Jiaxin, Zhou Hao-Wei, Zhang Xi, Wang Xin, Li Chun-Hua, Chen Fang-Yao, Gao Ke, Zhang Jie, Guan Yong-Juan, Chang John, Yang Tie-Lin, Mu Jian-Jun

Abstract excerpt

OBJECTIVE: Pregnancy-associated plasma protein-A2 (PAPP-A2) is the homolog of PAPP-A in the vertebrate genome and its role in protecting against salt-induced hypertension in salt-sensitive rats has been confirmed. We sought to examine the associations of plasma PAPP-A2 levels and its genetic variants with salt sensitivity, blood pressure (BP) changes and hypertension incidence in humans. METHODS: Eighty...

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PMID: 33783375
DOI: 10.1097/HJH.0000000000002846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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