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Article

Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro.

PloS one - 1 Jan 2021

Carney Bonnie C, Travis Taryn E, Moffatt Lauren T, Johnson Laura S, McLawhorn Melissa M, Simbulan-Rosenthal Cynthia M, Rosenthal Dean S, Shupp Jeffrey W

Abstract excerpt

There are limited treatments for dyschromia in burn hypertrophic scars (HTSs). Initial work in Duroc pig models showed that regions of scar that are light or dark have equal numbers of melanocytes. This study aims to confirm melanocyte presence in regions of hypo- and hyper-pigmentation in an animal model and patient samples. In a Duroc pig model, melanocyte presence was confirmed using en face staining. Patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33765043
DOI: 10.1371/journal.pone.0248985
PMCID: PMC7993611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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