Article
Inflated false discovery rate due to volcano plots: problem and solutions.
Briefings in bioinformatics - 2 Sept 2021
Ebrahimpoor Mitra, Goeman Jelle J
Abstract excerpt
MOTIVATION: Volcano plots are used to select the most interesting discoveries when too many discoveries remain after application of Benjamini-Hochberg's procedure (BH). The volcano plot suggests a double filtering procedure that selects features with both small adjusted $P$-value and large estimated effect size. Despite its popularity, this type of selection overlooks the fact that BH does not guarantee error...
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